Enjoy thrilling outdoor excursions at some of the best locales in Patagonia, the untamed region that makes up the southern cone of South America. It begins with culture in Chile's dazzling capital of Santiago before heading south to the Lake District, known for its snowcapped volcanoes and glassy lakes. After embarking on nature hikes, cross into Argentina and the Swiss-inspired town of Bariloche, followed by multiday treks in the epicenters for such adventures: El Chaltén and Torres del Paine.

Highlights

  • Visit the finest museums and tour the most iconic landmarks in Santiago
  • Sip Chile's famous wines in the Casablanca Valley and tour coastal Valparaíso
  • Trek to active volcanoes and tranquil lakes in the Lake District
  • Hike among Patagonian national parks like Los Glaciares and Torres del Paine

Brief Itinerary

Day Highlights Overnight
Day 1 Arrive in Santiago (Chile), Explore the Capital Santiago
Day 2 Santiago Museum Tour Santiago
Day 3 Day Trip to Valparaíso & Casablanca Valley Santiago
Day 4 Fly to Puerto Varas & the Lake District Puerto Varas
Day 5 Trekking in Alerce Andino National Park Puerto Varas
Day 6 Day Trip to Osorno Volcano & Petrohué Falls Puerto Varas
Day 7 Transfer to Bariloche (Argentina) by Boat & Bus Bariloche
Day 8 Half-Day Circuito Chico Trek Bariloche
Day 9 Sailing Trip to Blest Port & Los Cantaros  Bariloche
Day 10 Day Trip to San Martín de los Andes Bariloche
Day 11 Fly to El Chaltén, Argentina's Trekking Capital El Chaltén
Days 12-14 Self-Guided Hikes in El Chaltén El Chaltén
Day 15 Transfer to El Calafate, Gateway to Glaciers El Calafate
Day 16 Day Trip to Perito Moreno & Boat Tour El Calafate
Day 17 Transfer to Puerto Natales (Chile) Puerto Natales
Day 18 Full-Day Exploration of Torres del Paine National Park Puerto Natales
Day 19 Full-Day Lago Sarmiento Hike Puerto Natales
Day 20 Fly to Santiago, Free Afternoon Santiago
Day 21 Depart Santiago  

Detailed Itinerary

Day 1: Arrive in Santiago (Chile), Explore the Capital

Chile's Plaza de Armas is home to its most famous historic landmarks, like the Metropolitan Cathedral

Welcome to Chile! This narrow sliver of a country in western South America may appear small, but it abounds with natural beauty. One of its most famous regions is Patagonia, which covers the entire southern cone of both Chile and Argentina. This rugged, unspoiled paradise offers some of the most thrilling outdoor adventures anywhere in the world.

You'll experience Patagonia's splendor soon enough—today, the journey begins in the nation's capital Santiago. Upon arrival at Santiago's airport, a driver will pick you up and transfer you to your hotel in the city. After checking in, you can hit the streets on a self-guided tour. Begin at Palacio de la Moneda, Chile's opulent presidential palace, and continue a short way to Plaza de Armas, the city's main square. Among other historical landmarks, it's home to the Palacio de la Real Audiencia (Palace of the Royal Court), built in 1808, which houses the National History Museum of Chile.

Then, hike up Cerro Santa Lucía, a lovely park and remnant of an ancient volcano. Conquistadors used this hill as a lookout in the 16th century, and it was here that Pedro de Valdivia officially founded Santiago in 1541. After stopping by other famous landmarks, like the Museum of Fine Arts, continue to the bohemian Bellavista neighborhood and relax at a café before returning to your hotel.

Day 2: Santiago Museum Tour

Walk through Indigenous history at Santiago's Museo Chileno de Arte Precolombino

Chile's history runs deeper than even its Spanish colonial landmarks. This morning, take a deep dive into Chile's pre-Hispanic roots, plus its more recent political turmoil, on a private tour of two of Santiago's finest museums. First up is the Museo Chileno de Arte Precolombino (Museum of pre-Columbian Art), located in the historic center near the Plaza de Armas. This renowned institution preserves and showcases the diverse cultures of Indigenous Americans prior to European contact. Highlights include textiles and weavings, pottery and ceramics, ceremonial objects, sculptures, and mummies.

The next stop is the Museo de la Memoria y los Derechos Humanos (Museum of Memory and Human Rights). This space was created to preserve the history and memories of human rights violations committed by Chile's military dictatorship, led by Augusto Pinochet, between 1973 and 1990. Through exhibits, testimony, and historical records, it gives voice to the thousands of victims and their families. It also promotes tolerance and human rights to ensure that this dark chapter of history never repeats itself.

Day 3: Day Trip to Valparaíso & Casablanca Valley

Wander up hilly streets and past colorful cafés in Valparaíso

After breakfast, you'll meet a local guide and hit the road on a full-day tour. It's a 1.5-hour drive west from Santiago to Valparaíso, one of the most colorful coastal cities in the world. During this scenic journey, you'll pass the hills and vineyards of the fertile Casablanca Valley, home to many top wineries. During a stop here, you'll tour a vineyard and sample a few Chilean wines, like the famous carménère varietal.

Eventually, you'll reach the coast and the historic port city of Valparaíso. This UNESCO World Heritage Site is famous for its funky hillside neighborhoods, winding stairways, and abundance of street art. It's a well-preserved snapshot of a time when electric trolleys coasted through downtown in front of Art Nouveau buildings.

You'll visit famous landmarks, such as Plaza de la Victoria and the Naval Academy, and ride a rumbling funicular elevator up into the hills to enjoy panoramic vistas of the Pacific. A real highlight is visiting La Sebastiana, the coastal home (now a museum) of Pablo Neruda. Afterward, you'll return to Santiago.

Day 4: Fly to Puerto Varas & the Lake District

Kick back and enjoy volcano views from your hotel in Puerto Varas

Say hasta luego to Santiago! This morning, your driver will transfer you to the airport for the two-hour flight to the port city of Puerto Montt in Chile's gorgeous Lake District, where snowcapped volcanoes meet forested islands dotted with shimmering lakes. From there, it's a 30-minute drive north to Puerto Varas, which sits on the vast shores of Lago Llanquihue. Known as "the City of Roses," Puerto Varas is home to elegant plazas full of roses (hence the nickname) and alpine-style architecture.

From its streets you can look out across the lake to the snowcapped cones of the nearby Osorno and Calbuco volcanoes. The town is also a hub for Lake District adventures—from here, you can hike, ski, climb various volcanoes, fish, raft, and go horseback riding. Tonight, enjoy a fusion of traditional European-style cuisine and classic Chilean flavors at dinner, then turn in early to rest up for tomorrow's adventures.

Day 5: Trekking in Alerce Andino National Park

Hike deep into the Valdivian rainforest in Alerce Andino

Lace up your hiking boots because this morning, you'll transfer to the coastal town of Lenca, the gateway to Alerce Andino National Park. Home to lush Valdivian rainforest, the park covers a large peninsula east of Puerto Montt, spanning 970,000 acres (40,000 ha) of valleys, turquoise lagoons, and alerce forests. Alerces are the largest and oldest trees in South America, which can grow nearly 200 feet (60 m) and live as long as 2,500 years.

Your guided trek through the park follows the edge of rivers and lakes through giant, temperate forests abounding with mañio, tepa, arrayán, and alerce trees, finally reaching Lago Quetrus, a mountain lake. The shores around the lake are home to various wildlife, such as rare coscoroba swans, pumas, cougars, foxes, and other bird species. At the end of the half-day trek, you'll return to Puerto Varas and can spend the evening relaxing.

Day 6: Day Trip to Osorno Volcano & Petrohué Falls

Spend the day traveling around the rivers and waterfalls surrounding Osorno

After breakfast at your hotel, a driver will pick you up for a full-day scenic tour of the area's famous volcanoes and waterfalls. The first part of the drive takes you along the shores of Lago Llanquihue, where it meets the mouth of the Río Pescado. After passing the charming villages of La Poza and Los Riscos, you'll arrive at Ensenada, a small town at the foot of Osorno. From a trailhead, you'll hike about halfway up the volcano to an impressive lookout at 4,068 feet (1,240 m) above sea level.

When the hike is complete, you'll break for lunch and continue to the famous Río Petrohué waterfall. Fed by the nearby Lago Todos Los Santos, Petrohué is famous for its electric blue waters and cascading falls that have carved a network of chutes into the surrounding basaltic lava rock. There are various pathways around here that offer different vantage points where you can observe these thundering falls in all their glory. The tour finishes with a visit to the turquoise waters of Todos los Santos before returning to Puerto Varas in time to enjoy dinner in town.

Day 7: Transfer to Bariloche (Argentina) by Boat & Bus

Bariloche is the crown jewel of Argentina's Lake District

Wake up early and embark on a full-day excursion that will take you from Chile to Argentina. The trip involves boat rides across three lakes plus overland bus trips. Throughout the 12-hour journey, you'll enjoy views of glaciers, volcanic peaks, and alpine forests on your way to San Carlos de Bariloche.

This mountain resort destination is the largest city in Argentina's Lake District, a region home to some of the most impressive scenery in the entire country. Bariloche was founded in 1902 on the southeastern shore of Lago Nahuel Huapi, part of the larger Parque Nacional Nahuel Huapi. The name comes from the Mapuche native people who once inhabited the area ("Nahuel Huapi" means "Jaguar Island"). Upon arrival, you'll check into your hotel and can unwind after the long day.

Day 8: Half-Day Circuito Chico Trek

For the best views around Bariloche, you've got to hit the trails
Plan your trip to Patagonia
Chat with a local specialist who can help organize your trip.

In the morning, meet your guide and embark on a half-day excursion that follows the famous Circuito Chico (Short Circuit) tourist route. You'll follow the lakeshore west from the city to Playa Bonita, a tranquil pebble beach that looks out to Isla Huemul. Then, continue to some of the area's most famous viewpoints, like Cerro Campanario and the Llao Llao Peninsula. The former is a mountain offering panoramic views of Lago Nahuel Huapi from its summit, while the latter is the site of the most impressive hotel in the country, Hotel Llao Llao.

Continue over a bridge that crosses the Río Angostura, which joins the lakes of Moreno and Nahuel Huapi. You'll then stop at another fine lookout point to snap photos. Afterward, head to Laguna el Trebol, a small lagoon surrounded by woodlands. From there, you'll turn back toward Bariloche and complete the circuit. Throughout the tour, your guide will impart knowledge about the region's rich Indigenous history.

Day 9: Sailing Trip to Blest Port & Los Cantaros 

Blest Port and Los Cantaros Fall Sailing
Explore the remote corners of Nahuel Huapi on a boat tour

Return to the water this morning as you sail across Nahuel Huapi on a full-day boat tour. It starts with an overland transfer to Puerto Pañuelo, where you'll board the boat and set off along a far-eastern arm of the lake. Highlights include visiting the enchanting island of Centinela, marveling at the terraced falls of Cascada de los Cántaros, and hiking through temperate rainforest. You can opt to finish in the charming lakeside town of Puerto Blest or continue on to the emerald waters of Lago Frías before returning to Bariloche for the evening.

Day 10: Day Trip to San Martín de los Andes

Travel to the scenic lake villages around Bariloche, like Villa La Angosturato 

In the morning, you'll meet your driver for a full-day road trip to experience the majesty of the Lake District. You'll follow the scenic Seven Lakes Road: a 66-mile (107 km) route that connects the lake towns of San Martín de Los Andes and Villa La Angostura. On this jaw-dropping journey, you'll see magnificent landscapes as you pass through two national parks. These include rich coihue forests and azure lakes like Falkner, Escondido, and Nahuel Huapi.

As you pass one such lake, Correntoso, you'll arrive in the small town of Ruca Malén. Then, continue to San Martín de los Andes, a charming town located on the shores of Lago Lacar. After visiting the town and snapping photos around the impressive waterfront, you'll return to Bariloche in the afternoon.

Day 11: Fly to El Chaltén, Argentina's Trekking Capital

Looming over El Chaltén is the granite massif of Mount Fitz Roy

It's time to bid a fond farewell to the Lake District as you journey deeper into Argentine Patagonia. After breakfast, your driver will transfer you to the airport in Bariloche, and you'll take a connecting flight to El Chaltén. This town lies above Lago Viedma and is a major hub for mountain hikes (it's actually known as the "trekking capital of Argentina"), as nearby is the iconic massif of Mount Fitz Roy.

Upon arrival, another driver will pick you up for the transfer to your hotel in town. Then, you'll have the rest of the day free. If you like, embark on a short, self-guided hike or spend time relaxing at one of El Chaltén's many cafés and craft beer bars. 

Days 12-14: Self-Guided Hikes in El Chaltén

Hit the trail early and see the sunrise at Laguna de los Tres

The next three days are free for you to choose your own adventures in the Patagonian wilderness. The area surrounding El Chaltén offers a wide range of hiking paths with varying levels of difficulty, all of which are maintained and well-marked. One easy option from town includes a 1.9-mile (3 km) walk to Cerro Torre viewpoint, where you can enjoy views of the Río Las Vueltas, lenga beech forests, and plentiful birdlife, including woodpeckers. You can also extend the hike from Cerro to other impressive viewpoints around Mount Fitz Roy and the emerald waters of Laguna de los Tres

Beginners can try an easy, 2-3 mile (3-5 km) round-trip trek to Mirador de los Cóndores or a one-hour hike to the Chorrillo del Salto waterfall. A more challenging option is trekking up to the Huemul Glacier, located about an hour outside El Chaltén and named after the elusive south Andean deer. This moderately strenuous journey will take you through some of the most gorgeous scenery in the area, including rivers, streams, and pristine forests. A nice reward is the view of Cerro Torre and Mount Fitz Roy from the top.

One longer trek is the memorable route to Laguna Torre. Leaving town, you'll cross a glacial valley that's long fascinated geologists due to its perfect "U" shape, the result of the area once being covered by large swaths of ice. The 12-mile (20 km) trail will take you through bright green forests and around lagoons until you reach the shores of Laguna Torre.

Day 15: Transfer to El Calafate, Gateway to Glaciers

El Calafate is the gateway to the awe-inspiring Perito Moreno Glacier
Board a shuttle this morning for the 3.5-hour ride south from El Chaltén to El Calafate. Sitting on the southern shore of Lago Argentino, this town is the gateway to the massive Southern Patagonian Ice Field, home to Los Glaciares National Park. Within this protected area is the region's star, Perito Moreno, a 96-square-mile (250 sq km) ice formation that is one of the few advancing glaciers in the world. Upon arrival at the airport, a driver will transfer you to your hotel, and you'll have the rest of the day free.

Day 16: Day Trip to Perito Moreno Glacier & Boat Tour

View Perito Moreno from surrounding boardwalks, then hop on a boat to get up close

Meet your driver this morning and head out on a tour of Los Glaciares National Park. The ride there takes about an hour, and as you enter the park, you'll catch your first glimpse of the mighty Perito Moreno. This expansive glacier flows down from the Andes over the turquoise waters of Lago Argentino, ending in a great wall that curves around the lake. You can enjoy views of this marvel of Mother Nature via a network of wooden boardwalks on the waterfront (be sure to take plenty of photos).

Then, you'll head over to the port at Bajo de Las Sombras and board a boat for a one-hour tour of the glacier's southern face. The first 20 minutes of the trip will take you past icebergs floating on the lake. These are the result of "calving," a periodic occurrence when ice breaks off the face of the glacier. Eventually, you'll get up close with Perito Moreno's massive ice wall reaching 230 feet (70 m). After the hourlong tour, you'll return to the port and transfer back to El Calafate.

Day 17: Transfer to Puerto Natales (Chile)

Rest up in Puerto Natales for tomorrow's big day out in Torres del Paine

In the morning, you'll board a bus for the six-hour transfer south out of Argentina and back into Chile and Puerto Natales. This small port city on the Seno Última Esperanza (Last Hope Sound) is famous as a base for nature excursions in Torres del Paine, the crown jewel of Chile's national parks. This legendary protected area covers 700 square miles (1,810 sq km) and is renowned for its circuit treks. Upon arrival, you'll transfer to your hotel and can relax as you prepare for tomorrow's adventure in Torres del Paine.

Day 18: Full-Day Exploration of Torres del Paine National Park

Explore the glacial lakes and waterfalls of Torres del Paine

Set out on an action-packed day exploring Torres del Paine National Park, a UNESCO-listed gem that's one of Chile's most-visited parks. After a pickup at your hotel, your first stop will be near the park at the Milodón Cave. In 1895, an explorer found fragments of a giant extinct mylodon here—an extinct bear-like creature from 10,000 years ago (there's a replica of the giant mylodon in the cave). En route, you can also snap pics of the Silla del Diablo (Devil's Chair) rock formation nearby.

Once you've looked around the cave, continue north along the road to Torres del Paine National Park to reach Lago Grey, where you can walk to the scenic viewpoint. Enjoy lunch at a local restaurant, then head to the park's Salto Grande sector, where the beautiful Lago Nordenskjöld and thundering Paine Waterfall await. On the way back to Puerto Natales, stop at the Lago Sarmiento viewpoint to grab some epic photos with a backdrop of snowcapped mountains.

Day 19: Full-Day Lago Sarmiento Hike

Look out for guanacos on today's hike to Lago Sarmiento

Return to Torres del Paine this morning on a full-day, 4.3-mile (7 km) hike around the east side of the park. First, you'll arrive at a viewpoint looking out over Lago Sarmiento, the second-largest lake in Torres del Paine. It's the perfect spot to snap epic photos of the mountain landscapes as well as the guanacos that live in the area.

Continue to Laguna Amarga, notable for the alkaline waters that result in its glassy, shimmering surface. There's another stop nearby at Laguna Blanquillos, a lagoon and haven for endemic birds like black-necked swans. The hike continues to a rocky outcropping adorned with 20 cave paintings that date back about 6,000 years. Follow the path up to the Sarmiento Lake gatehouse, where you'll enjoy a box lunch and a peaceful respite before making the return journey to Puerto Natales.

Day 20: Fly to Santiago, Free Afternoon 

Stroll past vintage houses and street art in Bellavista, Santiago's bohemian center
Time to head back north. After breakfast, your driver will transfer you to the airport for the three-hour flight back to Santiago. There, you'll transfer to your hotel and can spend the day relaxing and rejuvenating after all those mountain treks. If you like, celebrate your final night with dinner out at a chic restaurant in Santiago's trendy Bellavista neighborhood.

Day 21: Depart Santiago

A sunset over Santiago and the Andes
You've experienced the highlights and hidden gems of Argentine and Chilean Patagonia, now it's time to move on to the next grand adventure. In the morning, your driver will pick you up for the transfer to the airport, where your flight home awaits. Until next time!

More Great Patagonia Itineraries

Looking for more inspiration for your trip to Patagonia? Check out these other Patagonia itineraries, with outdoor adventures, cultural trips, and best-of tours to hit the highlights. 

Map

Map of From the Andes to the Lakes: Trekking Adventures Across Patagonia - 21 Days
Map of From the Andes to the Lakes: Trekking Adventures Across Patagonia - 21 Days