The Vine House—Quinta São Luiz, Peso da Régua

Immerse yourself in the wine-making traditions of the Douro Valley with a stay at The Vine House, an almost 400-year-old property that's now a stylish hotel set just 1.5 hours from Porto. Located in Tabuaço just above the Douro River, The Vine House is an old family port-making home on the Quinta São Luiz estate, which produces some of the region's best wines. If you're looking for non-wine activities, you can visit the Museu de Lamego, 30 minutes away, housed in an 18th-century palace, or check out the 25,000-year-old cave carvings near Vila Nova de Foz Côa, 1.5 hours away.

Rooms are chic and modern, employing a mix of neutral tones, clean lines, and burgundy red tiles that evoke the land's wine production. All rooms are spacious, and some have balconies or terraces overlooking the Douro River and Valley, which are a particularly nice place to enjoy a glass of wine. Bathrooms are sleek with white and deep red tiles, all including large rainfall shower heads.

A highlight of this hotel is its pool, which overlooks the Douro River and is a great place to sit with a glass of wine or port. The on-site restaurant is in the breakfast room and has a handful of options; if you'd like to try something else, be prepared to drive around 30 minutes to reach a supermarket or other eateries.